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Pwen esansyèl Soti nan 63yèm Reyinyon Anyèl ASH
Done senyen atravè nivo ekspresyon debaz FIX nan moun ki gen emofili B: yon analiz ki itilize 'Etid ekspresyon faktè.
Tom Burke, MSc1,2 *, Anum Shaikh2*, Talaha Ali3*, Nanxin Li, PhD, MBA4, Barbara A Konkle, MD5, Declan Noone, MSc6*, Brian O'Mahony, FACSLM7,8 *, Steven W. Pipe, MD9, ak Jamie O'Hara, MSc1,2 *
1Fakilte Sante ak Swen Sosyal, University of Chester, Chester, Wayòm Ini
2HCD Ekonomi, Daresbury, Wayòm Ini
3uniQure, Lexington, MA
4uniQure, Lexington, MA
5Inivèsite Washington, Washington Sant pou maladi senyen, Seattle, WA
6Ewopeyen Haemophilia Consortium, Brussels, Bèljik
7Trinity College Dublin, Dublin, Iland
8Irish Haemophilia Society, Dublin, Iland
9Depatman Pedyatri ak Patoloji, University of Michigan, Ann Arbor, MI
Kle Done Pwen
Done ki soti nan de etid maladi (CHESS EU I-II ak CHESS US / US +) yo te itilize nan yon modèl lineyè jeneralize (GLM), ak lyen log pou evalye asosyasyon ki genyen ant nivo ekspresyon ABR ak FIX (FEL) nan pasyan ki gen emofili. B. Nan tout pasyan ki enkli nan analiz la (N = 407), mwayèn FEL (SD) te 9.95 IU/dL (10.5) ak mwayèn ABR (SD) te 2.4 senyen/ane (3.6). Yo montre pi wo a senyen yo prevwa kòm yon fonksyon FEL pwodwi pa modèl la. Apre ajisteman pou laj, BMI, ak viris san yo, ABR mwayèn nan modèl la diminye pa 0.8 inite pou chak ogmantasyon 1% nan FEL (P <0.001).
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