• Discuss up-to-date information on the current and emerging approaches for treating hemophilia, including various approaches of gene therapy

DISCLOSURE POLICY
In accordance with the ACCME Standards for Commercial Support, The France Foundation (TFF) and the International Society on Thrombosis and Haemostasis (ISTH) require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TFF and ISTH resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, TFF and ISTH seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and ISTH are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Activity Staff Disclosures
The planners, reviewers, editors, staff, CME committee, and other members at The France Foundation who control content have no relevant financial relationships to disclose.

The planners, reviewers, editors, staff, CME committee, and other members at the International Society on Thrombosis and Haemostasis who control content have no relevant financial relationships to disclose.

Faculty Disclosures–Activity Faculty
The following faculty report that they have relevant financial relationships to disclose:

• Barbara Konkle, MD, serves as a consultant for Biomarin, Regeneron, Pfizer, Inc., Sanofi, Sigilon, and Takeda. She has received research funding from Octapharma, Pfizer, Inc., Sanofi, Spark Therapeutics, and Takeda.

Faculty Disclosures–Planning Committee

The faculty listed below report that they have no relevant financial relationships to disclose:

• Alok Srivastava, MD, FRACP, FRCPA, FRCP

The following faculty report that they have relevant financial relationships to disclose:

• Pratima Chowdary, MRCP, FRCPath, receives research grant support from Bayer, CSL Behring, Novo Nordisk, Pfizer, and Sobi. She serves as a consultant for Baxter, Biogen, CSL Behring, Freeline, Novo Nordisk, Pfizer, Roche, Shire, and Sobi.
• David Lillicrap, MD, serves as a consultant for BioMarin, CSL Behring, Sanofi, and Takeda. He receives research support from Bayer, BioMarin, CSL Behring, Octapharma, and Sanofi.
• Wolfgang Miesbach, MD, PhD, receives grant research support from Bayer, Biotest, CSL Behring, LFB, Novo Nordisk, Octapharma, Pfizer, and Takeda/Shire. He serves on the speakers' bureau for Bayer, BioMarin, Biotest, CSL Behring, Chugai, LFB, Novo Nordisk, Octapharma, Pfizer, Roche, and Takeda/Shire. Dr. Miesbach serves on advisory boards for Bayer, BioMarin, Biotest, CSL Behring, Chugai, Freeline, LFB, Novo Nordisk, Octapharma, Pfizer, Roche, Sanofi, Takeda/Shire, and uniQure.
• Margareth Ozelo, MD, PhD, serves as consultant for BioMarin, Novo Nordisk, Pfizer, Roche, Sanofi, and Takeda. She serves on the speakers' bureau for Bayer, BioMarin, Novo Nordisk, Roche, and Takeda. Dr. Ozelo conducts contract research for BioMarin, Novo Nordisk, Pfizer, Roche, Sanofi, Spark, and Takeda.
• Flora Peyvandi, MD, PhD, serves as a consultant for Sanofi and Sobi. She serves on the speakers bureau for Bioverativ, Grifols, Roche, Sanofi, Sobi, Spark, and Takeda.
• Glenn F. Pierce, MD, PhD, receives honoraria for academic consulting from BioMarin, Genentech/Roche, Pfizer, St. Jude, and VarmX. He holds leadership positions with Global Blood Therapeutics, NHF MASAC, and World Federation of Hemophilia.
• Steven W. Pipe, MD, serves as a consultant for Apcintex, ASC Therapeutics, Bayer, BioMarin Catalyst Biosciences, CSL Behring, HEMA Biologics, Freeline, Novo Nordisk, Pfizer, Roche/Genentech, Sangamo Therapeutics, Sanofi, Takeda, Spark Therapeutics, and uniQure
• Johnny Mahlangu, BSc, MBBCh, MMed, FCPath, serves on the speakers bureau and does contract research for CSL Behring, Catalyst Biosciences, Freeline Therapeutics, Novo Nordisk, Roche, Sanofi, Spark, and Takeda
• Thierry VandenDriessche, PhD, holds leadership positions with NHF and ISTH. He receives research funding from Pfizer and Takeda. Dr. VandenDriessche receives honoraria from Baxalta, Shire, Takeda, Bayer, Biotest, and Pfizer.

The France Foundation (TFF) and the International Society on Thrombosis and Haemostasis (ISTH) require CME faculty (speakers) to disclose when products or procedures being discussed are off-label, unlabeled, experimental and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF and ISTH do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.

This activity is supported by independent medical educational grants from BioMarin, Sanofi Genzyme, CSL Behring, and Spark Therapeutics.

The France Foundation and the International Society on Thrombosis Haemostasis present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, the International Society on Thrombosis Haemostasis, and the commercial supporter(s) assume no liability for the information herein.

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